I Putu Alit Pawana, MD
Dr. Soetomo General Hospital Surabaya
CMAX including Forceplate
" I think CMAX is one of the best tools for motion and gait analysis measurement"

Upgrading of our gait laboratory provides an extraordinary atmosphere in our lab. The old gait lab condition from complexity turns into simplicity. All measurement and analysis became user friendly.

Gait problem is our concern to help patient reach better quality of life. Gait pathology can be analyzed using CMAX. By using this software we can assess gait deviations through the ground reaction force and kinematic changes.

Analysis of the ground reaction force and kinematic will determine the appropriate prescription for the patient ; and revisions to the orthoses and prostheses will be easier with accurate measurement.


The effect of oral curcumin supplementation and immobilization on skeletal muscle fiber diameter of rattus norvegicus (Pawana IPA, Haryadi RD)

Title journal
The effect of oral curcumin supplementation and immobilization on skeletal muscle fiber diameter of rattus norvegicus
Media Folia Medica Indonesiana

Immobilization may result in skeletal muscle atrophy, in which the diameter of muscle fiber is decreased.
The stimulus response at cellular level presents as the activation of Tumor Necrosis Factor (TNF)-ï•¡ and
NF-ï•«B (Nuclear Factor-ï•«B), which results in the degradation of muscular protein. Curcumin is a yellow
pigment substance commonly found in plants belonging to the genus Curcuma longa (kunyit) and Curcuma
xanthorrhiza Robx (temulawak). One of the actions of Curcumin is inhibition of the NF-ï•«B pathway
activation. The objective of this study was to analyze the effect of oral curcumin and immobilization on the
diameter of skeletal muscle fiber of Rattus norvegicus. Subjects of the study were male Rattus norvegicus
aged 3-4 months, with bodyweight of 150-200 grams. Subjects were divided into three groups, a control
group,an immobilization group without curcumin, and an immobilization group with oral curcumin, each
of which comprised 11 subjects. Immobilization using a splint was applied to the soleus muscle for 2 weeks.
Oral curcumin was given to the immobilization group in a dose of 400 mg/rats (2 g/KgBW) single dose
once a week. The diameter of soleus muscle was measured histopathologically with HE staining, under a
light microscope using a magnification of 400x. Results showed that the diameter of skeletal muscle fiber in
the immobilization group was reduced 42.41% and 26,48% in the immobilization group with curcumin
supplementation the reduction was 26.48%, as compared to the control group. There was significant
difference (p < 0.05) in the diameter of skeletal muscle fiber between control, immobilization, and
immobilization with curcumin supplementation groups. In conclusion, the addition of oral curcumin
significantly reduces atrophy of soleus muscle in rats immobilized for 2 weeks.

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